研究室 行動生理学講座 −動物実験施設
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高雄啓三倉林伸博藤井一希、大橋りえ、小池誠一
学会報告の一覧はこちらをご覧ください

(2020)
Takeuchi M, Sakai T, Andocs G, Takao K, Nagaoka R, Hasegawa H. Temperature elevation in tissue detected in vivo based on statistical analysis of ultrasonic scattered echoes. Sci Rep. 2020 Jun 3;10(1):9030. doi: 10.1038/s41598-020-65562-4. PMID: 32493998; PMCID: PMC7270122. 

Takeuchi H, Imamura K, Ji B, Tsukita K, Enami T, Takao K, Miyakawa T, Hasegawa M, Sahara N, Iwata N, Inoue M, Hara H, Tabira T, Ono M, Trojanowski JQ, Lee VM, Takahashi R, Suhara T, Higuchi M, Inoue H. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ Vaccines. 2020 Mar 24;5:28. doi: 10.1038/s41541-020-0172-y. PMID: 32219000; PMCID: PMC7096417. 

Nishizono H, Darwish M, Uosaki H, Masuyama N, Seki M, Abe H, Yachie N, Yasuda R. Use of Freeze-thawed Embryos for High-efficiency Production of Genetically Modified Mice. J Vis Exp. 2020 Apr 2;(158). doi: 10.3791/60808. PMID: 32310226. 

Nakamoto C, Kawamura M, Nakatsukasa E, Natsume R, Takao K, Watanabe M, Abe M, Takeuchi T, Sakimura K. GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior. PLoS One. 2020 Feb 20;15(2):e0229288. doi: 10.1371/journal.pone.0229288. PMID: 32078638; PMCID: PMC7032715.

Nishizono H, Darwish M, Endo TA, Uno K, Abe H, Yasuda R. Glycine receptor α4 subunit facilitates the early embryonic development in mice. Reproduction. 2020 Jan;159(1):41. doi: 10.1530/REP-19-0312. PMID: 31689234. 

Reveiw
Ohashi R, Shiina N. Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules. Biomolecules . 2020 Jan 22;10(2):167. doi: 10.3390/biom10020167.

(2019)
Fujii K, Otofuji H, Nakamura Y, Koshidaka Y, Adachi M, Sasakawa E, Darwish M, Takao K. Comprehensive behavioral analysis of mice repeatedly treated with propofol. Translational and Regulatory Sciences 2019 Nov; 1(2) 46 - 57. doi.org/10.33611/trs.1_46.

Nakajima R, Takao K, Hattori S, Shoji H, Komiyama NH, Grant SGN, Miyakawa T. Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice. Neuropsychopharmacol Rep. 2019 Sep;39(3):223-237. doi: 10.1002/npr2.12073. Epub 2019 Jul 19. PMID: 31323176. 

Steinecke A, Kurabayashi N, Hayano Y, Ishino Y, Taniguchi H. In Vivo Single-Cell Genotyping of Mouse Cortical Neurons Transfected With CRISPR/Cas9. Cell Rep . 2019 Jul 9;28(2):325-331.e4. doi: 10.1016/j.celrep.2019.06.038.  

Darwish M, Nishizono H, Uosaki H, Sawada H, Sadahiro T, Ieda M, Takao K. Rapid and high-efficient generation of mutant mice using freeze-thawed embryos of the C57BL/6J strain. J Neurosci Methods. 2019 Apr 1;317:149-156. doi: 10.1016/j.jneumeth.2019.01.010. Epub 2019 Jan 23. PMID: 30684509.

Nunomura S, Ejiri N, Kitajima M, Nanri Y, Arima K, Mitamura Y, Yoshihara T, Fujii K, Takao K, Imura J, Fehling HJ, Izuhara K, Kitajima I. Establishment of a Mouse Model of Atopic Dermatitis by Deleting Ikk2 in Dermal Fibroblasts. J Invest Dermatol. 2019 Jun;139(6):1274-1283. doi: 10.1016/j.jid.2018.10.047. Epub 2019 Jan 19. PMID: 30670308.

Hattori S, Okumura Y, Takao K, Yamaguchi Y, Miyakawa T. Open source code for behavior analysis in rodents. Neuropsychopharmacol Rep. 2019 Mar;39(1):67-69. doi: 10.1002/npr2.12047. Epub 2019 Jan 18. PMID: 30659767.

Ueno H, Fujii K, Takao K, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T. Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice. Mol Cell Neurosci. 2019 Mar;95:31-42. doi: 10.1016/j.mcn.2018.12.008. Epub 2019 Jan 2. PMID: 30610998.

Fujii K, Koshidaka Y, Adachi M, Takao K. Effects of chronic fentanyl administration on behavioral characteristics of mice. Neuropsychopharmacol Rep. 2019 Mar;39(1):17-35. doi: 10.1002/npr2.12040. Epub 2018 Dec 1. PMID: 30506634.

Koshimizu H, Hirata N, Takao K, Toyama K, Ichinose T, Furuya S, Miyakawa T. Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. Neuropsychopharmacol Rep. 2019 Mar;39(1):56-60. doi: 10.1002/npr2.12041. Epub 2018 Nov 24. PMID: 30472790.  

Misc
高雄 啓三, 「学問の府から見た武道の意義」 月刊「武道」 635(2019年10月号) 74 - 79 2019年10月  

(2018)
Katano T, Takao K, Abe M, Yamazaki M, Watanabe M, Miyakawa T, Sakimura K, Ito S. Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery. Mol Brain. 2018 Oct 25;11(1):63. doi: 10.1186/s13041-018-0407-2. PMID: 30359304; PMCID: PMC6202847.

Andoh C, Nishitani N, Hashimoto E, Nagai Y, Takao K, Miyakawa T, Nakagawa T, Mori Y, Nagayasu K, Shirakawa H, Kaneko S. TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. Brain Res. 2019 Feb 1;1704:68-77. doi: 10.1016/j.brainres.2018.09.031. Epub 2018 Sep 28. PMID: 30273551.

Inoue R, Talukdar G, Takao K, Miyakawa T, Mori H. Dissociated Role of D-Serine in Extinction During Consolidation vs. Reconsolidation of Context Conditioned Fear. Front Mol Neurosci. 2018 May 22;11:161. doi: 10.3389/fnmol.2018.00161. PMID: 29872376; PMCID: PMC5972189.

Okuda K, Takao K, Watanabe A, Miyakawa T, Mizuguchi M, Tanaka T. Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory. PLoS One. 2018 Apr 27;13(4):e0196587. doi: 10.1371/journal.pone.0196587. PMID: 29702698; PMCID: PMC5922552.

Hattori S, Takao K, Funakoshi H, Miyakawa T. Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (Tdo2) knockout mice. Neuropsychopharmacol Rep. 2018 Jun;38(2):52-60. doi: 10.1002/npr2.12006. Epub 2018 Mar 15. PMID: 30106261.

Ueno H, Fujii K, Suemitsu S, Murakami S, Kitamura N, Wani K, Aoki S, Okamoto M, Ishihara T, Takao K. Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex. IBRO Rep. 2018 Feb 8;4:22-37. doi: 10.1016/j.ibror.2018.01.002. PMID: 30135949; PMCID: PMC6084874.

Ueno H, Takao K, Suemitsu S, Murakami S, Kitamura N, Wani K, Okamoto M, Aoki S, Ishihara T. Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex. Neurochem Int. 2018 Jan;112:59-70. doi: 10.1016/j.neuint.2017.11.001. Epub 2017 Nov 7. PMID: 29126935. 

書籍 
西園啓文、高雄啓三 バイオ実験を安全に行うために 化学同人 4章 生物試料の取扱 4.5 実験動物 ISBN: 4759819215

西園啓文、高雄啓三 基礎心理学実験法ハンドブック 朝倉書店 付録1 被験体とその飼育方法 1.2 マウス ISBN: 4254520239

(2017)
Yoshioka N, Miyata S, Tamada A, Watanabe Y, Kawasaki A, Kitagawa H, Takao K, Miyakawa T, Takeuchi K, Igarashi M. Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis. Mol Brain. 2017 Oct 5;10(1):47. doi: 10.1186/s13041-017-0328-5. PMID: 28982363; PMCID: PMC5629790.

Umeda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, Tomiyama T. Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice. Acta Neuropathol Commun. 2017 Jul 31;5(1):59. doi: 10.1186/s40478-017-0461-5. PMID: 28760161; PMCID: PMC5537936.

Umemura M, Ogura T, Matsuzaki A, Nakano H, Takao K, Miyakawa T, Takahashi Y. Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice. Front Behav Neurosci. 2017 Jul 11;11:125. doi: 10.3389/fnbeh.2017.00125. PMID: 28744205; PMCID: PMC5504141.

Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T. Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. J Exp Med. 2017 May 1;214(5):1431-1452. doi: 10.1084/jem.20161517. Epub 2017 Apr 13. PMID: 28408410; PMCID: PMC5413336.

Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A. Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis. J Neurochem. 2017 Apr;141(1):124-136. doi: 10.1111/jnc.13963. Epub 2017 Feb 21. PMID: 28122138. 

(2016)
Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T. QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior. PLoS One. 2016 Nov 11;11(11):e0164716. doi: 10.1371/journal.pone.0164716. PMID: 27835635; PMCID: PMC5105951. 

Morishita Y, Yoshioka Y, Takimura Y, Shimizu Y, Namba Y, Nojiri N, Ishizaka T, Takao K, Yamashita F, Takuma K, Ago Y, Nagano K, Mukai Y, Kamada H, Tsunoda S, Saito S, Matsuda T, Hashida M, Miyakawa T, Higashisaka K, Tsutsumi Y. Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice. ACS Nano. 2016 Sep 27;10(9):8180-91. doi: 10.1021/acsnano.6b01782. Epub 2016 Aug 15. PMID: 27498759.

Takao K, Shoji H, Hattori S, Miyakawa T. Cohort Removal Induces Changes in Body Temperature, Pain Sensitivity, and Anxiety-Like Behavior. Front Behav Neurosci. 2016 Jun 3;10:99. doi: 10.3389/fnbeh.2016.00099. PMID: 27375443; PMCID: PMC4891333. 

Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S. Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Sci Rep. 2016 Jun 2;6:27204. doi: 10.1038/srep27204. PMID: 27251103; PMCID: PMC4890022. 

Ohashi R, Takao K, Miyakawa T, Shiina N. Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. Sci Rep. 2016 Feb 11;6:20775. doi: 10.1038/srep20775. PMID: 26865403; PMCID: PMC4749962.

Shoji H, Takao K, Hattori S, Miyakawa T. Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age. Mol Brain. 2016 Jan 28;9:11. doi: 10.1186/s13041-016-0191-9. PMID: 26822304; PMCID: PMC4730600. 


高雄教授の赴任前の業績はこちらでご確認ください。

 


連絡先:takao [at] cts.u-toyama.ac.jp