(2023)
Ni X, inoue R, Wu Y, Yoshida T, Yaku K, Nakagawa T, Saito T, Saido TC, Takao K, Mori H., Regional contributions of D-serine to Alzheimer’s disease pathology in male App^{NL−G−F/NL−G−F} mice. Front Aging Neurosci 2023  15:1211067

Darwish M, Hattori S, Nishizono H, Miyakawa T, Yachie N, Takao K., Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency. Mol Brain 2023 16:44 

Ping, Y. Ohata, K. Kikushima, K. Sakamoto, T. Islam, A. Xu, L. Zhang, H. Chen, B. Yan, J. Eto, F. Nakane, C. Takao, K. Miyakawa, T. Kabashima, K. Watanabe, M. Kahyo, T. Yao, I. Fukuda, A. Ikegami, K. Konishi, Y. Setou, M. Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain. Biomolecules 2023, 13(5): 784. doi: 10.3390/biom13050784.

Yamashita A, Shichino Y, Fujii K, Koshidaka Y, Adachi M, Sasagawa E, Mito M, Nakagawa S, Iwasaki S, Takao K, Shiina N. ILF3 prion-like domain regulates gene expression and fear memory under chronic stress. iScience. 2023 Feb 19;26(3):106229. doi: 10.1016/j.isci.2023.106229. eCollection 2023 Mar 17.

(2022)
Miyamoto Y, Koshidaka Y, Murase K, Kanno S, Noguchi H, Miyado K, Ikeya T, Suzuki S, Yagi T, Teramoto N, Hayashi S. Functional Evaluation of 3D Liver Models Labeled with Polysaccharide Functionalized Magnetic Nanoparticles. Materials (Basel) . 2022 Nov 5;15(21):7823. doi: 10.3390/ma15217823.

Kawai T, Narita H, Konno K, Akter S, Andriani RT, Iwasaki H, Nishikawa S, Yokoi N, Fukata Y, Fukata M, Wiriyasermkul P, Kongpracha P, Nagamori S, Takao K, Miyakawa T, Abe M, Sakimura K, Watanabe M, Nakagawa A, Okamura Y.Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum. Biochem J. 2022 Jun 17;479(11):1127-1145. doi: 10.1042/BCJ20220033. PMID: 35574701

Oota-Ishigaki A, Takao K, Yamada D, Sekiguchi M, Itoh M, Koshidata Y, Abe M, Natsume R, Kaneko M, Adachi T, Kaizuka T, Suzuki N, Sakimura K, Okuno H, Wada K, Mishina M, Miyakawa T, Hayashi T. Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice. Neuropsychopharmacology. 2022 May 26. doi: 10.1038/s41386-022-01347-9. Online ahead of print.

(2021)
Takeuchi M, Sakai T, Andocs G, Takanaka T, Taka M, Yamashita K, Kawahara M, Nojiri T, Tanaka A, Norishima A, Omoto Y, Omura M, Nagaoka R, Takao K, Hasegawa H. Statistical Analysis of Ultrasonic Scattered Echoes Enables the Noninvasive Measurement of Temperature Elevations inside Tumor Tissue during Oncological Hyperthermia. Ultrasound in Medicine & Biology. 2021 Nov;47(11):3301-3309. doi: 10.1016/j.ultrasmedbio.2021.07.019. Epub 2021 Aug 24.

Sugiyama T,  Murao N, Kadowaki H, Takao K,  Miyakawa T, Matsushita Y,  Katagiri T, Futatsugi A, YoheiShinmyo Y, Kawasaki H, Sakai J, Shiomi K, Nakazato M, Takeda K, Mikoshiba K, Ploegh HL, Ichijo H, Nishitoh H. ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience. 2021 Jul 23;24:7 102758. doi: 10.1016/j.isci.2021.102758    
プレスリリース  

Hori T, Ikuta S, Hattori S, Takao K, Miyakawa T, Koike C. Mice with mutations in Trpm1, a gene in the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior. Mol Brain. 2021 Mar 30;14(1):61. doi: 10.1186/s13041-021-00749-y.PMID: 33785025

Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, Saitoh T, Maenaka K, Shimada T, Fukata Y, Fukata M, Matsumoto J, Nishijo H, Takao K, Tanaka S, Okabe S, Tabuchi K, Uemura T, Mishina M, Mori H, Fukai S.Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice. Nat Commun. 2021 Mar 23;12(1):1848. doi: 10.1038/s41467-021-22059-6. PMID: 33758193
プレスリリース

Kawai T, Takao K, Akter S, Abe M, Sakimura K, Miyakawa T, Okamura Y. Heterogeneity of microglial proton channel in different brain regions and its relationship with aging. J Neurochem. 2021 Jan 6. doi: 10.1111/jnc.15292. Online ahead of print. PMID: 33404063

書籍
藤井一希, 高雄 啓三 マウス・ラットモデル作製・解析プロフェッショナル〜あなたの研究をステップアップさせる最新・最適手技 羊土社 第３章 生理機能の解析 第２節 マウスの網羅的行動解析の実施とその注意点 ISBN:978-4-7581-2112-5 2021年03月18日発行  

(2020)
Nguyen QL, Okuno N, Hamashima T, Dang ST, Fujikawa M, Ishii Y, Enomoto A, Maki T, Nguyen HN, Nguyen VT, Fujimori T, Mori H, Andrae J, Betsholtz C, Takao K, Yamamoto S, Sasahara M. Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice. Angiogenesis. 2020 Sep 12. doi: 10.1007/s10456-020-09742-w. Online ahead of print. PMID: 32918673

Sakayori N, Katakura M, Hamazaki K, Higuchi O, Fujii K, Fukabori R, Iguchi Y, Setogawa S, Takao K, Miyazawa T, Arita M, Kobayashi KMaternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring's overeating in mice. Commun Biol. 2020 Aug 28;3(1):473. doi: 10.1038/s42003-020-01209-4. PMID: 32859990  

Takeuchi M, Sakai T, Andocs G, Takao K, Nagaoka R, Hasegawa H. Temperature elevation in tissue detected in vivo based on statistical analysis of ultrasonic scattered echoes. Sci Rep. 2020 Jun 3;10(1):9030. doi: 10.1038/s41598-020-65562-4. PMID: 32493998; PMCID: PMC7270122. 

Takeuchi H, Imamura K, Ji B, Tsukita K, Enami T, Takao K, Miyakawa T, Hasegawa M, Sahara N, Iwata N, Inoue M, Hara H, Tabira T, Ono M, Trojanowski JQ, Lee VM, Takahashi R, Suhara T, Higuchi M, Inoue H. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ Vaccines. 2020 Mar 24;5:28. doi: 10.1038/s41541-020-0172-y. PMID: 32219000; PMCID: PMC7096417. 

Nishizono H, Darwish M, Uosaki H, Masuyama N, Seki M, Abe H, Yachie N, Yasuda R. Use of Freeze-thawed Embryos for High-efficiency Production of Genetically Modified Mice. J Vis Exp. 2020 Apr 2;(158). doi: 10.3791/60808. PMID: 32310226. 

Nakamoto C, Kawamura M, Nakatsukasa E, Natsume R, Takao K, Watanabe M, Abe M, Takeuchi T, Sakimura K. GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior. PLoS One. 2020 Feb 20;15(2):e0229288. doi: 10.1371/journal.pone.0229288. PMID: 32078638; PMCID: PMC7032715.

Nishizono H, Darwish M, Endo TA, Uno K, Abe H, Yasuda R. Glycine receptor α4 subunit facilitates the early embryonic development in mice. Reproduction. 2020 Jan;159(1):41. doi: 10.1530/REP-19-0312. PMID: 31689234. 

Reveiw
Ohashi R, Shiina N. Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules. Biomolecules. 2020 Jan 22;10(2):167. doi: 10.3390/biom10020167.

(2019)
Fujii K, Otofuji H, Nakamura Y, Koshidaka Y, Adachi M, Sasakawa E, Darwish M, Takao K. Comprehensive behavioral analysis of mice repeatedly treated with propofol. Translational and Regulatory Sciences, 2019 Nov; 1(2) 46 - 57. doi.org/10.33611/trs.1_46.

Nakajima R, Takao K, Hattori S, Shoji H, Komiyama NH, Grant SGN, Miyakawa T. Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice. Neuropsychopharmacol Rep. 2019 Sep;39(3):223-237. doi: 10.1002/npr2.12073. Epub 2019 Jul 19. PMID: 31323176. 

Steinecke A, Kurabayashi N, Hayano Y, Ishino Y, Taniguchi H. In Vivo Single-Cell Genotyping of Mouse Cortical Neurons Transfected With CRISPR/Cas9. Cell Rep.  2019 Jul 9;28(2):325-331.e4. doi: 10.1016/j.celrep.2019.06.038.  

Darwish M, Nishizono H, Uosaki H, Sawada H, Sadahiro T, Ieda M, Takao K. Rapid and high-efficient generation of mutant mice using freeze-thawed embryos of the C57BL/6J strain. J Neurosci Methods. 2019 Apr 1;317:149-156. doi: 10.1016/j.jneumeth.2019.01.010. Epub 2019 Jan 23. PMID: 30684509.

Nunomura S, Ejiri N, Kitajima M, Nanri Y, Arima K, Mitamura Y, Yoshihara T, Fujii K, Takao K, Imura J, Fehling HJ, Izuhara K, Kitajima I. Establishment of a Mouse Model of Atopic Dermatitis by Deleting Ikk2 in Dermal Fibroblasts. J Invest Dermatol. 2019 Jun;139(6):1274-1283. doi: 10.1016/j.jid.2018.10.047. Epub 2019 Jan 19. PMID: 30670308.

Hattori S, Okumura Y, Takao K, Yamaguchi Y, Miyakawa T. Open source code for behavior analysis in rodents. Neuropsychopharmacol Rep. 2019 Mar;39(1):67-69. doi: 10.1002/npr2.12047. Epub 2019 Jan 18. PMID: 30659767.

Ueno H, Fujii K, Takao K, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T. Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice. Mol Cell Neurosci. 2019 Mar;95:31-42. doi: 10.1016/j.mcn.2018.12.008. Epub 2019 Jan 2. PMID: 30610998.

Fujii K, Koshidaka Y, Adachi M, Takao K. Effects of chronic fentanyl administration on behavioral characteristics of mice. Neuropsychopharmacol Rep. 2019 Mar;39(1):17-35. doi: 10.1002/npr2.12040. Epub 2018 Dec 1. PMID: 30506634.

Koshimizu H, Hirata N, Takao K, Toyama K, Ichinose T, Furuya S, Miyakawa T. Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. Neuropsychopharmacol Rep. 2019 Mar;39(1):56-60. doi: 10.1002/npr2.12041. Epub 2018 Nov 24. PMID: 30472790.  

Misc
高雄 啓三, 「学問の府から見た武道の意義」 月刊「武道」 635(2019年10月号) 74 - 79 2019年10月  

(2018)
Katano T, Takao K, Abe M, Yamazaki M, Watanabe M, Miyakawa T, Sakimura K, Ito S. Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery. Mol Brain. 2018 Oct 25;11(1):63. doi: 10.1186/s13041-018-0407-2. PMID: 30359304; PMCID: PMC6202847.

Andoh C, Nishitani N, Hashimoto E, Nagai Y, Takao K, Miyakawa T, Nakagawa T, Mori Y, Nagayasu K, Shirakawa H, Kaneko S. TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. Brain Res. 2019 Feb 1;1704:68-77. doi: 10.1016/j.brainres.2018.09.031. Epub 2018 Sep 28. PMID: 30273551.

Inoue R, Talukdar G, Takao K, Miyakawa T, Mori H. Dissociated Role of D-Serine in Extinction During Consolidation vs. Reconsolidation of Context Conditioned Fear. Front Mol Neurosci. 2018 May 22;11:161. doi: 10.3389/fnmol.2018.00161. PMID: 29872376; PMCID: PMC5972189.

Okuda K, Takao K, Watanabe A, Miyakawa T, Mizuguchi M, Tanaka T. Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory. PLoS One. 2018 Apr 27;13(4):e0196587. doi: 10.1371/journal.pone.0196587. PMID: 29702698; PMCID: PMC5922552.

Hattori S, Takao K, Funakoshi H, Miyakawa T. Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (Tdo2) knockout mice. Neuropsychopharmacol Rep. 2018 Jun;38(2):52-60. doi: 10.1002/npr2.12006. Epub 2018 Mar 15. PMID: 30106261.

Ueno H, Fujii K, Suemitsu S, Murakami S, Kitamura N, Wani K, Aoki S, Okamoto M, Ishihara T, Takao K. Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex. IBRO Rep. 2018 Feb 8;4:22-37. doi: 10.1016/j.ibror.2018.01.002. PMID: 30135949; PMCID: PMC6084874.

Ueno H, Takao K, Suemitsu S, Murakami S, Kitamura N, Wani K, Okamoto M, Aoki S, Ishihara T. Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex. Neurochem Int. 2018 Jan;112:59-70. doi: 10.1016/j.neuint.2017.11.001. Epub 2017 Nov 7. PMID: 29126935. 

書籍 
西園啓文、高雄啓三 バイオ実験を安全に行うために 化学同人 4章 生物試料の取扱 4.5 実験動物 ISBN: 4759819215

西園啓文、高雄啓三 基礎心理学実験法ハンドブック 朝倉書店 付録１ 被験体とその飼育方法 1.2 マウス ISBN: 4254520239

(2017)
Yoshioka N, Miyata S, Tamada A, Watanabe Y, Kawasaki A, Kitagawa H, Takao K, Miyakawa T, Takeuchi K, Igarashi M. Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis. Mol Brain. 2017 Oct 5;10(1):47. doi: 10.1186/s13041-017-0328-5. PMID: 28982363; PMCID: PMC5629790.

Umeda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, Tomiyama T. Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice. Acta Neuropathol Commun. 2017 Jul 31;5(1):59. doi: 10.1186/s40478-017-0461-5. PMID: 28760161; PMCID: PMC5537936.

Umemura M, Ogura T, Matsuzaki A, Nakano H, Takao K, Miyakawa T, Takahashi Y. Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice. Front Behav Neurosci. 2017 Jul 11;11:125. doi: 10.3389/fnbeh.2017.00125. PMID: 28744205; PMCID: PMC5504141.

Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T. Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. J Exp Med. 2017 May 1;214(5):1431-1452. doi: 10.1084/jem.20161517. Epub 2017 Apr 13. PMID: 28408410; PMCID: PMC5413336.

Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A. Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis. J Neurochem. 2017 Apr;141(1):124-136. doi: 10.1111/jnc.13963. Epub 2017 Feb 21. PMID: 28122138. 

(2016)
Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T. QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior. PLoS One. 2016 Nov 11;11(11):e0164716. doi: 10.1371/journal.pone.0164716. PMID: 27835635; PMCID: PMC5105951. 

Morishita Y, Yoshioka Y, Takimura Y, Shimizu Y, Namba Y, Nojiri N, Ishizaka T, Takao K, Yamashita F, Takuma K, Ago Y, Nagano K, Mukai Y, Kamada H, Tsunoda S, Saito S, Matsuda T, Hashida M, Miyakawa T, Higashisaka K, Tsutsumi Y. Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice. ACS Nano. 2016 Sep 27;10(9):8180-91. doi: 10.1021/acsnano.6b01782. Epub 2016 Aug 15. PMID: 27498759.

Takao K, Shoji H, Hattori S, Miyakawa T. Cohort Removal Induces Changes in Body Temperature, Pain Sensitivity, and Anxiety-Like Behavior. Front Behav Neurosci. 2016 Jun 3;10:99. doi: 10.3389/fnbeh.2016.00099. PMID: 27375443; PMCID: PMC4891333. 

Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S. Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Sci Rep. 2016 Jun 2;6:27204. doi: 10.1038/srep27204. PMID: 27251103; PMCID: PMC4890022. 

Ohashi R, Takao K, Miyakawa T, Shiina N. Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. Sci Rep. 2016 Feb 11;6:20775. doi: 10.1038/srep20775. PMID: 26865403; PMCID: PMC4749962.

Shoji H, Takao K, Hattori S, Miyakawa T. Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age. Mol Brain. 2016 Jan 28;9:11. doi: 10.1186/s13041-016-0191-9. PMID: 26822304; PMCID: PMC4730600. 

高雄教授の赴任前の業績はこちらでご確認ください。

連絡先：takao [at] cts.u-toyama.ac.jp